The researchers identified stem cells within the skin's fatty layer and showed that molecular signals from these cells were necessary to spur hair growth in mice, according to research published in the Sept. 2 issue of the journal Cell.
"If we can get these fat cells in the skin to talk to the dormant stem cells at the base of hair follicles, we might be able to get hair to grow again," said Valerie Horsley, assistant professor of molecular, cellular and developmental biology and senior author of the paper.
Men with male pattern baldness still have stem cells in follicle roots but these stem cells lose the ability to jump-start hair regeneration. Scientists have known that these follicle stem cells need signals from within the skin to grow hair, but the source of those signals has been unclear.
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Horsley's team observed that when hair dies, the layer of fat in the scalp that comprises most of the skin's thickness shrinks. When hair growth begins, the fat layer expands in a process called adipogenesis. Researchers found that a type of stem cell involved in creation of new fat cells -- adipose precursor cells -- was required for hair regeneration in mice. They also found these cells produce molecules called PDGF (platelet derived growth factors), which are necessary to produce hair growth.
Horsley's lab is trying to identify other signals produced by adipose precursor stem cells that may play a role in regulating hair growth. She also wants to know whether these same signals are required for human hair growth. Other authors from Yale are lead author Eric Festa, Jackie Fretz, Ryan Berry, Barbara Schmidt, Matthew Rodeheffer and Mark Horowitz.
Drinking carrot juice, unlike some supplements that oncologists prohibit during conventional treatment, is perfectly compatible with simultaneous radiation or chemo; but I didn't want the recommended chemo because I had researched and dreaded its side effects. So I had no chemo, no radiation, no other treatments, and no dietary changes beyond the carrot consumption, and continuing eating meat and ice cream and indulging in other dietary vices (I don't recommend ice cream for cancer, but only want to emphasize that drinking carrot juice was the only change I made in my life, besides gratefully accepting prayers and "good energy" from friends and asking for wisdom and help from Whoever is up there in the Beyond. On January 7, after eight weeks on the carrot juice (a quart to a quart and one third daily) I had my first follow-up CT scan. It showed no growth of the cancer, some shrinkage of the tumors, and fewer swollen lymph nodes. In just eight weeks, the growth of the tumors had stopped. It's interesting that eight weeks is the same amount of time on carrot juice that it took Ralph to eliminate his cell tumors. Alkaline diet (also known as the alkaline ash diet, alkaline acid diet, acid ash diet, and the acid alkaline diet) describes a group of loosely related diets based on the belief that certain foods can affect the acidity and pH of bodily fluids, including the urine or blood, and can therefore be used to treat or prevent diseases.
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The relationship between diet and acid-base homeostasis, or the regulation of the acid-base status of the body, has been studied for decades, though the medical applications of this theory have largely focused on changing the acidity of urine. Traditionally, this diet has advocated for avoiding meat, poultry, cheese, and grains in order to make the urine more alkaline (higher pH), changing the environment of the urine to prevent recurrent urinary tract infections (UTIs) and kidney stones (nephrolithiasis). However, difficulties in effectively predicting the effects of this diet have led to medications, rather than diet modification, as the preferred method of changing urine pH. The "acid-ash" hypothesis has been considered a risk factor for osteoporosis by various scientific publications, though more recently, the available weight of scientific evidence does not support this hypothesis. The term "alkaline diet" has also been used by alternative medicine practitioners, with the proposal that such diets treat or prevent cancer, heart disease, low energy levels as well as other illnesses. These claims are not supported by medical evidence and make incorrect assumptions about how alkaline diets function that are contrary to modern understanding of human physiology. 316